A naturally occurring tetrapeptide from thymosin beta-4, Thymosin Beta-4 Fragment (1-4) (Ac-SDKP) has anti-inflammatory, pro-angiogenic, and anti-scarring qualities. It may be used as a treatment for diseases such as inflammatory bowel disease, kidney/liver fibrosis, and cardiovascular disease. Because of its association with the angiotensin-converting enzyme, it may also offer a more natural method of managing high blood pressure.